Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic.

Navya Malladi Ebin Johny Shravan K Uppulapu Vikas Tiwari Md Jahangir Alam Ramu Adela Sanjay Kumar Banerjee

Published in: Journal of diabetes research (2021)

We observed an inhibitory effect of allyl methyl sulfide on platelet aggregation, platelet activation, platelet macrophage interaction, and increased ROS levels in type 1 diabetes. Our data suggests that AMS can be useful to control cardiovascular complication in diabetes via inhibition of platelet activation.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
cell death
adipose tissue
dna damage
electronic health record
metabolic syndrome
insulin resistance
big data
artificial intelligence
oxidative stress
deep learning