Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation.

Gopinath Kasetty Ravi Kiran Varma BhongirPraveen PapareddyEllen TufvessonHenning StenbergLeif BjermerAnna Hultgårdh-NilssonHeiko HerwaldArne Egesten

Published in: Allergy (2018)

OPN reduces inflammation, decreases tissue injury, and reduces bacterial loads during concurrent pneumococcal infection and allergic airway inflammation in a murine model. These findings suggest that OPN significantly affects vulnerability to pneumococcal infection in atopic asthma.

Keyphrases

allergic rhinitis
oxidative stress
chronic obstructive pulmonary disease
climate change
squamous cell carcinoma
lung function
cystic fibrosis
locally advanced