Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association With Genetic and Clinical Characteristics.

Sian Louise GraceJack BowdenHelen C WalkeyAkaal KaurShivani MisraBeverley M ShieldsTrevelyan J McKinleyNick S OliverTimothy J McDonaldDesmond G JohnstonAngus G JonesKashyap Amratlal Patel

Published in: The Journal of clinical endocrinology and metabolism (2022)

Islet autoantibody levels provide additional information over positivity in T1D at diagnosis. Bimodality of GADA and IA-2A autoantibody levels highlights the novel aspect of heterogeneity of T1D. This may have implications for T1D prediction, treatment, and pathogenesis.

Keyphrases

type diabetes
single cell
genome wide
glycemic control
healthcare
insulin resistance
copy number
metabolic syndrome
gene expression
adipose tissue