Quantifying Uncertainty in Ecotoxicological Risk Assessment: MUST, a Modular Uncertainty Scoring Tool.

Whether conducting a risk, hazard, or alternatives assessment, one invariably struggles with the task of reconciling multiple available values of toxicological thresholds into a single outcome. When combining multiple pieces of evidence from many different sources, it is important to consider the role of data uncertainty. Uncertainty is inherent to all scientific data. However, in toxicological assessments, controversies and uncertainties are typically understated; they lack methodological transparency; or they poorly integrate qualitative and quantitative sources of information. Similarly, in model development, data curation is rarely performed with sufficient rigor, particularly when applying big data statistics. To overcome the hurdles of a decision process that must reconcile divergent data, we developed an uncertainty scoring tool that can be trained to reproduce specific decision-making paradigms and ensure consistency in the practitioner's judgment across complex scenarios. While designed to aid with ecotoxicological assessments and predictive model development, the tool's applicability extends to any decision-making process that calls for synthesis of incongruent data. Here, we highlight the development process, as well as demonstrate the method's utility in several prototypical ecotoxicological case studies.