A Comparative Analysis of the Gene Expression Profiles in the Mammary Glands of Lactating and Nonlactating Mares at the Second Month of Gestation.
Tseweendolmaa UlaangerelMin WangBilig ZhaoMinna YiYingchao ShenYibeeltu MengkhXin WenManglai DugarjavGerelchimeg BouPublished in: Animals : an open access journal from MDPI (2024)
To investigate molecular regulation involved in lactation during pregnancy, this study focused on the transcriptomic profiles of mammary tissue from lactating and non-lactating Mongolian mares at the second month of gestation. A total of 4197 differentially expressed genes were identified by comparing mammary tissues from pregnant mares at two different states, including 1974 differentially expressed genes such as the milk protein-related genes a-s1-casein ( CSN1S1 ), k-casein ( CSN3 ), lactalbumin ( LALBA ), and lactoferrin ( LTF ), which were highly expressed in the lactating mares group, and overall, these differentially expressed genes were mainly associated with biological processes such as endoplasmic reticulum protein processing, the Toll-like receptor signaling pathway, steroid biosynthesis, cytokine-cytokine receptor interactions, and amino sugar and nucleotide glycolysis. These findings serve as a foundation for investigating the molecular underpinnings of lactation in pregnant equids.
Keyphrases
- dairy cows
- toll like receptor
- gene expression
- endoplasmic reticulum
- genome wide
- signaling pathway
- preterm infants
- heat stress
- bioinformatics analysis
- genome wide identification
- nuclear factor
- dna methylation
- pregnant women
- inflammatory response
- immune response
- binding protein
- gestational age
- amino acid
- genome wide analysis
- epithelial mesenchymal transition
- transcription factor
- cell wall