Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances.

Lucia MrázikováSilvie HojnáAndrea PačesováLucie HrubáVeronika StrnadováBarbora NeprašováBlanka ŽeleznáJaroslav KunešLenka Maletínská

Published in: Nutrition & diabetes (2022)

-PrRP31 had neuroprotective features without anti-obesity and glucose lowering effects in fa/fa rats. This data suggest that this analog has the potential to exert neuroprotective effect despite of leptin signaling disturbances in this rat model.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
cerebral ischemia
type diabetes
weight gain
high fat diet induced
body mass index
big data
adipose tissue
risk assessment
glycemic control