Optimization of an adenovirus-vectored zoster vaccine production process with chemically defined medium and a perfusion system.

Jianqi NieYang SunHe RenLingling HuangKai FengYe LiZhonghu Bai

Published in: Biotechnology letters (2022)

This optimization strategy could be used to develop a robust process with stable cell culture performance and adenovirus titer. Increasing PF-68 concentration in chemically defined medium could protect cells from shear stress generated by perfusion system.

Keyphrases

contrast enhanced
gene therapy
magnetic resonance imaging
magnetic resonance
computed tomography