Acetyl-CoA-driven respiration in frozen muscle contributes to the diagnosis of mitochondrial disease.

Felippe Henrique Zuccolotto-Dos-ReisSilvia Helena Andrião EscarsoJackeline Souza AraujoEnilza Maria EspreaficoLuciane Carla AlbericiClaudia Ferreira Da Rosa Sobreira

Published in: European journal of clinical investigation (2021)

We present preliminary data on a simple, low cost and reliable procedure to measure respiratory function in whole homogenates of frozen skeletal muscle biopsies, contributing to diagnosis of mitochondrial diseases in humans.

Keyphrases

skeletal muscle
low cost
oxidative stress
insulin resistance
electronic health record
minimally invasive
type diabetes
big data
respiratory tract