Rare Variants in the DNA Repair Pathway and the Risk of Colorectal Cancer.

Marco MatejcicHiba A ShabanMelanie W QuintanaFredrick R SchumacherChristopher K EdlundLeah NaghiRish K Pai Robert W HaileA Joan LevineDaniel D BuchananMark A JenkinsJane C FigueiredoGadi Rennert Stephen B GruberLi LiGraham CaseyDavid V ContiStephanie L Schmit

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2021)

This study provides new insights into the genetic predisposition to colorectal cancer, which has potential for translation into improved risk prediction.

Keyphrases

dna repair
dna damage
copy number
dna damage response
gene expression
risk assessment
human health
oxidative stress
dna methylation
climate change