Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function.
Francesca UlbarTiziana MontemurroTatiana JofraMiriam CapriGiorgia ComaiValentina BertuzzoCristiana LavazzaAlessandra MandelliMariele ViganòSilvia BudelliMaria Giulia BacaliniChiara PirazziniPaolo GaragnaniValeria GiudiceDaria SollazzoAntonio CurtiMario ArpinatiGaetano La MannaMatteo CesconAntonio Daniele PinnaClaudio FranceschiManuela BattagliaRosaria GiordanoLucia CataniRoberto Massimo LemoliPublished in: Journal of translational medicine (2019)
These data demonstrate that expanded/thawed GMP-Tregs from patients with end-stage organ disease are fully functional in vitro. Moreover, their infusion is safe and results in a trend toward reduced lethality of acute GVHD in vivo, further supporting Tregs-based adoptive immunotherapy in solid organ transplantation.
Keyphrases
- regulatory t cells
- cell therapy
- dendritic cells
- primary care
- healthcare
- liver failure
- low dose
- respiratory failure
- drug induced
- pregnant women
- stem cells
- intensive care unit
- escherichia coli
- quality improvement
- mesenchymal stem cells
- machine learning
- biofilm formation
- hepatitis b virus
- acute myeloid leukemia
- umbilical cord
- artificial intelligence