Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice.

Terese GeraghtyAlia M ObeidatShingo IshiharaMatthew J WoodJun LiErika Barboza Prado LopesCarla R ScanzelloTimothy M GriffinAnne-Marie MalfaitRachel E Miller

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Here we show that aging in male and female mice is accompanied by mild knee OA, mechanical sensitization, and changes to immune cell populations in the DRG, suggesting novel avenues for development of OA therapies. This article is protected by copyright. All rights reserved.

Keyphrases

knee osteoarthritis
neuropathic pain
high fat diet induced
chronic pain
spinal cord
pain management
insulin resistance
total knee arthroplasty
skeletal muscle
genetic diversity