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Increased HLA class II risk is associated with a more aggressive presentation of clinical type 1 diabetes.

Vilma KieleväinenMaaret TurtinenKristiina LuopajärviTaina HärkönenJorma IlonenOlli H Laitinennull null
Published in: Acta paediatrica (Oslo, Norway : 1992) (2022)
Children with stronger HLA disease susceptibility are younger at their disease manifestation and have a shorter period of symptoms before diagnosis, suggesting that the HLA class II genes are associated with a more aggressive disease presentation.
Keyphrases
  • type diabetes
  • young adults
  • case report
  • gene expression
  • metabolic syndrome
  • adipose tissue
  • dna methylation
  • skeletal muscle
  • physical activity
  • transcription factor
  • genome wide identification