p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet.

Marcus HollenbachNora KlötingInes SommererJana LorenzMario HeindlMatthias KernJoachim MössnerMatthias BlüherAlbrecht Hoffmeister

Published in: PloS one (2018)

p8 depletion may contribute to glucose metabolism via stress-induced insulin production and elevated beta cell mass. Nevertheless, p8 knockout showed no impact on insulin resistance in SD and HFD-fed mice.

Keyphrases

high fat diet
stress induced
insulin resistance
adipose tissue
single cell
high fat diet induced
type diabetes
cell therapy
wild type
stem cells
metabolic syndrome
bone marrow
mesenchymal stem cells