Clinical, immunologic, molecular analyses and outcomes of iranian patients with LRBA deficiency: A longitudinal study.

Gholamreza AziziHassan AbolhassaniSeyed Alireza MahdavianiZahra ChavoshzadehPeyman EshghiReza YazdaniFatemeh KiaeeMohammadreza ShaghaghiJavad MohammadiNima RezaeiLennart HammarströmAsghar Aghamohammadi

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2017)

LRBA deficiency has a very broad and variable phenotype and should be considered, especially in children with early-onset hypogammaglobulinemia, severe autoimmune manifestations, enteropathy, lymphoproliferation, and recurrent respiratory tract infections.

Keyphrases

early onset
respiratory tract
late onset
young adults
replacement therapy
multiple sclerosis
metabolic syndrome
adipose tissue
weight loss