Azacitidine and donor lymphocytes infusions in acute myeloid leukemia and myelodysplastic syndrome relapsed after allogeneic hematopoietic stem cell transplantation from alternative donors.
Carmine LiberatoreMaria Teresa Lupo StanghelliniFrancesca LorentinoLuca VagoMatteo Giovanni CarrabbaRaffaella GrecoSarah MarktelAndrea AssanelliFrancesca FarinaConsuelo CortiMassimo BernardiJacopo PeccatoriKatja SockelJan Moritz MiddekeJohannes ScheteligAnika BergmannChristina RautenbergFabio CiceriMartin BornhäuserThomas SchroederFriedrich StölzelPublished in: Therapeutic advances in hematology (2022)
AZA ± DLI proved feasible and effective in AML and MDS relapsing after HSCT from alternative donors. Despite modest efficacy among hematologic relapses, pre-emptive treatment with AZA ± DLI fared better in molecular relapse. Additional DLI contributed to improving efficacy and ensuring longer survival.