Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
François LamontagneMarie-Hélène MasseJulie MenardSheila SpragueRuxandra PintoDaren K HeylandDeborah J CookMarie-Claude BattistaAndrew G DayGordon H GuyattSalmaan KanjiRachael ParkeShay P McGuinnessBharath-Kumar Tirupakuzhi VijayaraghavanDjillali AnnaneDian CohenYaseen M ArabiBrigitte BolducNicole MarinoffBram RochwergTina MillenMaureen O MeadeLori HandIrene WatpoolRebecca PorteousPaul Jeffrey YoungFrederick D'AragonEmilie P Belley-CoteElaine CarbonneauFrance ClarkeDavid M MasloveMiranda HuntMichaël ChasséMartine LebrasseurFrançois LauzierSangeeta MehtaHector Quiroz-MartinezOleksa G RewaEmmanuel CharbonneyAndrew J E SeelyDemetrios J KutsogiannisRemi LeBlancArmand Mekontso-DessapTina S MeleAlexis F TurgeonGordon WoodSandeep S KohliJason ShahinPawel TwardowskiNeill K J Adhikarinull nullPublished in: The New England journal of medicine (2022)
In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John Hecht Memorial Foundation; LOVIT ClinicalTrials.gov number, NCT03680274.).