In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes.

Published in: Microbiology spectrum (2021)

Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates. The addition of avibactam to aztreonam had no effect on the anaerobic activity of aztreonam. IMPORTANCE This work shows that aztreonam-avibactam lacks activity against anaerobic organisms.

Keyphrases

gram negative
multidrug resistant
klebsiella pneumoniae
drug resistant
acinetobacter baumannii
microbial community
wastewater treatment
escherichia coli