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Characterizations of Elephant Endotheliotropic Herpesvirus Type 1A and 4 Co-Infections in Asian Elephant ( Elephas maximus ) Calves.

Khajohnpat BoonprasertSaralee SrivorakulNatcha MonchaivanakitWarangkhana LangkaphinSupaphen SripiboonThittaya JanyamethakulChannarong Srisa-AdThunyamas GuntawangJanine L BrownChatchote ThitaramKidsadagon Pringproa
Published in: Veterinary sciences (2024)
Three cases of double infection with elephant endotheliotropic herpesvirus (EEHV) types 1A and 4 in captive Asian elephants are presented. The first calf was a 4-year-old female that showed initial signs of lethargy and depression. The second calf was a 6-year-old female that displayed signs of depression and diarrhea and died within 48 h of the start of supportive treatment. The third was a 2-year-old male that died suddenly while living with the herd. Necropsies were performed in the first and second elephants, while only a tongue sample was collected from the third calf. EEHV infection was confirmed via quantitative PCR (qPCR) and gene sequencing, revealing double subtypes of EEHV1A and -4 infections. This study describes the hematological and pathological characteristics within the host following double EEHV infection.
Keyphrases
  • depressive symptoms
  • sleep quality
  • high resolution
  • copy number
  • gene expression
  • dna methylation
  • physical activity
  • transcription factor
  • combination therapy
  • clostridium difficile
  • irritable bowel syndrome