Denosumab Prevents Bone Loss and Microarchitectural Deterioration in Premenopausal Women With Breast Cancer Receiving Estradiol Suppression Therapy: A Randomized Controlled Trial.

Sabashini K RamchandAli Ghasem-ZadehRudolf HoermannShane WhiteBelinda Yeo Prudence A FrancisCecilia L H XuOlivia ColemanCatherine Shore-Lorenti Peter R Ebeling Jeffrey D ZajacEgo SeemanMathis Grossmann

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

Treatment with DMAB at commencement of estradiol suppression therapy preserves BMD, bone microarchitecture, and estimated strength, and is likely to increase fracture-free survival.

Keyphrases

bone loss
free survival
bone mineral density
postmenopausal women
bone marrow
mesenchymal stem cells
soft tissue
cell therapy
combination therapy