Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β-amyloid peptide (25-35)-induced memory impairment in mice.

Junpei TakahashiYudai UetaDaisuke YamadaSachie Sasaki-HamadaTakashi IwaiTomomi AkitaChikamasa YamashitaAkiyoshi SaitohJun-Ichiro Oka

Published in: Neuropsychopharmacology reports (2022)

Our results suggest that the oxytocin derivative is effective for its IN delivery to the brain and may be particularly useful in the clinical treatment of cognitive impairment, such as that characterizing AD.

Keyphrases

cognitive impairment
high glucose
white matter
resting state
high fat diet induced
drug induced
metabolic syndrome
functional connectivity
skeletal muscle
cerebral ischemia