Glycolysis-dominant metabolic pathway in cancer cells can promote their therapeutic resistance against radiotherapy (RT). Carbon monoxide (CO) as a glycolysis inhibitor can enhance the efficiency of RT. Herein, an X-ray responsive CO-releasing nanocomposite (HA@AuNC@CO) based on strong host-guest interactions between the radiosensitizer and CO donor for enhanced RT is developed. The encapsulated gold nanoclusters (CD-AuNCs) can effectively generate cytotoxic reactive oxygen species (ROS) under X-ray radiation, which not only directly inactivate cancer cells but also induce in situ CO gas generation from adamantane modified metal carbonyl (Ada-CO) for glycolysis inhibition. Both in vitro and in vivo results demonstrate that HA@AuNC@CO exhibits active targeting toward CD44 overexpressed cancer cells, along with excellent inhibition of glycolysis and efficient RT against cancer. This study offers a new strategy for the combination of gas therapy and RT in tumor treatment.
Keyphrases
- reactive oxygen species
- cancer therapy
- papillary thyroid
- high resolution
- room temperature
- dual energy
- squamous cell
- radiation therapy
- early stage
- dna damage
- lymph node metastasis
- stem cells
- electron microscopy
- gold nanoparticles
- locally advanced
- mass spectrometry
- silver nanoparticles
- quantum dots
- oxidative stress
- fluorescent probe
- carbon nanotubes
- reduced graphene oxide
- cell therapy
- solid phase extraction
- simultaneous determination