Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development.

Ronja S AdamSanne M van NeervenCayetano Pleguezuelos-ManzanoSalvatore SimminiNicolas LéveilléNina E de GrootAndrew N HoldingFlorian MarkowetzLouis Vermeulen

Published in: Cancer cell international (2020)

We observed that the region-specific cell identity has a substantial effect on the reaction to Wnt activation in a simple intestinal adenoma model. These findings provide a way forward in resolving the distinct biology between left- and right-sided human colon cancers with potential clinical relevance.

Keyphrases

single cell
cell proliferation
stem cells
cell therapy
endothelial cells
papillary thyroid
gene expression
risk assessment
induced pluripotent stem cells
childhood cancer
squamous cell
human health