Metyrapone abolishes Spike-Wave Discharge seizures in GAERS by reducing stress hormones.

Gabriella MartelloEzgi OzturkGeorgia HarrisCornelius PaulTerence J O'BrienNigel Charles Jones

Published in: Epilepsia (2023)

These results suggest that GAERS exhibit elevations in stress hormones, and this may contribute to seizures. Inhibiting corticosterone synthesis with metyrapone prevents seizures in GAERS, and shows potential for repurposing this drug as a future anti-seizure medication.

Keyphrases

temporal lobe epilepsy
signaling pathway
adverse drug
stress induced
current status
emergency department
climate change
drug induced