Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation.

Dina Leth Møller Katrine Kielsen Claus Henrik Nielsen Henrik Sengeløv Anders Elm Pedersen Lars Peter Ryder Klaus Müller

Published in: Immunopharmacology and immunotoxicology (2022)

In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

Keyphrases

allogeneic hematopoietic stem cell transplantation
flow cytometry
acute myeloid leukemia
end stage renal disease
ejection fraction
acute lymphoblastic leukemia
newly diagnosed
prognostic factors
bone marrow
peritoneal dialysis
hematopoietic stem cell
patient reported outcomes