Neuromodulatory effects of hesperidin in mitigating oxidative stress in streptozotocin induced diabetes.
Mohammad AshafaqLaxmi VarshneyMohammad Haaris Ajmal KhanMohd SalmanMehar NaseemSaima WajidHeena TabassumPublished in: BioMed research international (2014)
Oxidative stress has been implicated in pathogenesis of streptozotocin- (STZ-) induced diabetes mellitus and its complication in central nervous system (CNS). Recent studies have provided insights on antioxidants and their emergence as potential therapeutic and nutraceutical. The present study examined the hypothesis that hesperidin (HP) ameliorates oxidative stress and may be a limiting factor in the extent of CNS complication following diabetes. To test this hypothesis rats were divided into four groups: control, diabetic, diabetic-HP treated, and vehicle for HP treatment group. Diabetes mellitus was induced by a single injection of STZ (65 mg/kg body weight). Three days after STZ injection, HP was given (50 mg/kg b.wt. orally) once daily for four weeks. The results of the present investigation suggest that the significant elevated levels of oxidative stress markers were observed in STZ-treated animals, whereas significant depletion in the activity of nonenzymatic antioxidants and enzymatic antioxidants was witnessed in diabetic rat brain. Neurotoxicity biomarker activity was also altered significantly. HP treatment significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers. Our results demonstrate that HP exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model.
Keyphrases
- diabetic rats
- oxidative stress
- type diabetes
- ischemia reperfusion injury
- induced apoptosis
- dna damage
- body weight
- glycemic control
- wound healing
- cardiovascular disease
- blood brain barrier
- physical activity
- combination therapy
- hydrogen peroxide
- adipose tissue
- ultrasound guided
- insulin resistance
- high fat diet
- anti inflammatory
- endothelial cells
- smoking cessation
- nitric oxide
- white matter
- gestational age