High-Dose Vitamin C Alleviates Pancreatic Necrosis by Inhibiting Platelet Activation Through the CXCL12/CXCR4 Pathway in Severe Acute Pancreatitis.

Menglu GuiJun HuangHuiqiu ShengYing ChenZhi-Tao YangLi MaDaosheng WangLili XuWenwu SunJunling LiuYanyan XuErzhen ChenBing ZhaoEnqiang Mao

Published in: Journal of inflammation research (2023)

The present study suggests that high-dose Vit C can ameliorate pancreatic necrosis by improving microcirculation disorders of SAP. For the first time, the underlying mechanism is related with inhibiting platelet activation through the CXCL12/CXCR4 pathway.

Keyphrases

high dose
low dose
stem cell transplantation
signaling pathway
cell migration
early onset
mouse model