Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation.

Zhengchen SuThomas R SheliteYuan QiuQing ChangMaki WakamiyaJiani BeiXi HeChangcheng ZhouYakun LiuEmmanuel NyongYuejin LiangAngelo GaitasTais B SaitoBin Gong

Published in: Pathogens (Basel, Switzerland) (2021)

EPAC1 modulates rickettsial adhesion, in association with Y23 phosphorylation of the binding receptor ANXA2. Underlying mechanism(s) should be further explored to delineate the accurate role of cAMP-EPAC system during rickettsial infection.

Keyphrases

endothelial cells
protein kinase
binding protein
biofilm formation
high resolution
cell migration
pseudomonas aeruginosa
mass spectrometry