The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation.

Yanglin WuYun TengChenhui ZhangYing PanQin ZhangXu ZhuNaicheng LiuXinlin SuJun Lin

Published in: Journal of nanobiotechnology (2022)

In general, our study showed that the alleviation of osteolysis may owe to the effect of β-hydroxybutyrate (BHB) on inflammasome deactivation and osteoclast.

Keyphrases

nlrp inflammasome
diabetic rats
drug induced
stress induced