A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells.

Suneel RallapalliSoma GuhathakurtaDillip Kumar BishiRajasekaran SubbarayanSantosh MathapatiPurna Sai Korapatti

Published in: Biotechnology letters (2021)

Our results established that CBP supported culture of umbilical cord tissue-derived MSCs and is a safer Xeno free replacement to FBS. The use of CBP also enables the storage of umbilical cord tissue derived MSCs in patient-specific conditions to minimize adverse events if cells are delivered directly to the patient.

Keyphrases

umbilical cord
mesenchymal stem cells
bone marrow
induced apoptosis
case report
oxidative stress
cell death
signaling pathway
endoplasmic reticulum stress
monoclonal antibody