Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA.
Yong-Jun WangXia MengAnxin WangXuewei XieYuesong PanS Claiborne JohnstonHao LiPhilip M BathQiang DongLiangxue LaiJing JingJinxi LinSiying NiuYilong WangXingquan ZhaoZixiao LiYong JiangWei LiLiping LiuJie XuLiguo ChangLihua WangXianbo ZhuangJinguo ZhaoYefang FengHonghao ManGuozhong LiBaojun Wangnull nullPublished in: The New England journal of medicine (2021)
Among Chinese patients with minor ischemic stroke or TIA who were carriers of CYP2C19 loss-of-function alleles, the risk of stroke at 90 days was modestly lower with ticagrelor than with clopidogrel. The risk of severe or moderate bleeding did not differ between the two treatment groups, but ticagrelor was associated with more total bleeding events than clopidogrel. (Funded by the Ministry of Science and Technology of the People's Republic of China and others; CHANCE-2 ClinicalTrials.gov number, NCT04078737.).