Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction.
Jia-Rong JhengYang BaiKentaro NodaJoshua R HuotTodd CookAmanda FisherYi-Yun ChenDmitry A GoncharovElena A GoncharovaMarc A SimonYingze ZhangDaniel E FormanMauricio RojasRoberto F MachadoJohan AuwerxMark T GladwinYen-Chun LaiPublished in: Circulation (2024)
This study demonstrates a systemic pathogenic impact of skeletal muscle SIRT3 deficiency in remote pulmonary vascular remodeling and PH-HFpEF. This study suggests a new endocrine signaling axis that links skeletal muscle health and SIRT3 deficiency to remote CNPY2 regulation in the pulmonary vasculature through myokine LOXL2. Our data also identify skeletal muscle SIRT3, myokine LOXL2, and CNPY2 as potential targets for the treatment of PH-HFpEF.
Keyphrases
- skeletal muscle
- pulmonary hypertension
- insulin resistance
- oxidative stress
- ischemia reperfusion injury
- pulmonary artery
- healthcare
- pulmonary arterial hypertension
- replacement therapy
- mental health
- adipose tissue
- machine learning
- metabolic syndrome
- big data
- risk assessment
- social media
- smoking cessation
- artificial intelligence
- health promotion
- data analysis