Use of gallium-68 prostate-specific membrane antigen positron-emission tomography for detecting lymph node metastases in primary and recurrent prostate cancer and location of recurrence after radical prostatectomy: an overview of the current literature.
Henk B LuitingPim J van LeeuwenMartijn B BusstraTessa BrabanderHenk G van der PoelMaarten L DonswijkAndré N VisLouise EmmettPhillip D StrickerMonique J RoobolPublished in: BJU international (2019)
The review results showed that 68 Ga-PSMA PET had a high specificity for the detection of pelvic lymph node metastases in primary PCa. Furthermore, 68 Ga-PSMA PET had a very high positive predictive value in detecting lymph node metastases in patients with BCR. By contrast, sensitivity was only moderate; therefore, based on the currently available literature, 68 Ga-PSMA PET cannot yet replace pelvic lymph node dissection to exclude lymph node metastases. In the salvage phase, 68 Ga-PSMA PET had both a high detection rate and impact on radiotherapy planning in early BCR after RP.
Keyphrases
- pet ct
- lymph node
- prostate cancer
- positron emission tomography
- radical prostatectomy
- sentinel lymph node
- neoadjuvant chemotherapy
- acute lymphoblastic leukemia
- systematic review
- rectal cancer
- tyrosine kinase
- magnetic resonance
- early stage
- computed tomography
- locally advanced
- radiation therapy
- chronic myeloid leukemia
- sensitive detection