Association Between Opioid Dose Reduction Rates and Overdose Among Patients Prescribed Long-Term Opioid Therapy.

Jason M GlanzStanley XuKomal J NarwaneyDavid L McClureDeborah J RinehartMorgan A FordAnh P NguyenIngrid A Binswanger

Published in: Substance abuse (2023)

Patients receiving long-term opioid therapy exposed to dose reduction rates of >30% per month had increased overdose risk relative to patients exposed to stable dosing. Results support the use of slow dose reductions to minimize the risk of overdose.

Keyphrases

chronic pain
pain management
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
stem cells
mesenchymal stem cells
patient reported outcomes
bone marrow
replacement therapy