Association Between Opioid Dose Reduction Rates and Overdose Among Patients Prescribed Long-Term Opioid Therapy.
Jason M GlanzStanley XuKomal J NarwaneyDavid L McClureDeborah J RinehartMorgan A FordAnh P NguyenIngrid A BinswangerPublished in: Substance abuse (2023)
Patients receiving long-term opioid therapy exposed to dose reduction rates of >30% per month had increased overdose risk relative to patients exposed to stable dosing. Results support the use of slow dose reductions to minimize the risk of overdose.