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CD8+ T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
Ting Zeng
Ge Lv
Xuemei Chen
Lu Yang
Lina Zhou
Ying Dou
Xuemei Tang
Jun Yang
Yunfei An
Xiaodong Zhao
Published in:
Journal of clinical laboratory analysis (2020)
Unique immunologic abnormalities, CD8 T-cell senescence, and shortened telomere together as a hallmark occur in young DC patients before progression to severe disease.
Keyphrases
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end stage renal disease
dna damage
ejection fraction
endothelial cells
newly diagnosed
chronic kidney disease
peripheral blood
peritoneal dialysis
dendritic cells
early onset
immune response
patient reported outcomes
patient reported
drug induced