Inflammation can increase hepcidin in HFE-hereditary hemochromatosis.
Wenke MorisPauline L M VerhaeghAd A M MascleeDorine W SwinkelsCoby M LaarakkersGer H KoekCees Th B M van DeursenPublished in: Clinical case reports (2021)
We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.