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Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals.

Motonobu FujishimaYohei KawasakiToshiharu MitsuhashiHiroshi Matsudanull null
Published in: Alzheimer's research & therapy (2024)
In cognitively normal individuals, A + T + compounds brain atrophy and cognitive deterioration, amplifying the likelihood of disease progression. Therapeutic interventions targeting A + T + individuals could be pivotal in curbing brain atrophy, cognitive decline, and disease progression.
Keyphrases
  • cognitive decline
  • mild cognitive impairment
  • resting state
  • white matter
  • functional connectivity
  • cerebral ischemia
  • physical activity
  • multiple sclerosis
  • brain injury
  • cancer therapy
  • drug delivery
  • cerebrospinal fluid