Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction.
Maria A KerchevaAnna M GusakovaTamara R RyabovaTatiana E SuslovaJulia KzhyshkowskaVyacheslav V RyabovPublished in: Cells (2020)
Our research translates experimental data about the BMPs in the development of adverse LVR into the clinic. Elevated serum levels of BMPs decreased by the end of the six-month period after MI. BMP-2 decreased from the first day and BMP-4 decreased from Day 14. BMP-2 and BMP-4 were associated with the development of LVR. Their correlations with markers of inflammation, degradation of the extracellular matrix, hemodynamic stress and markers of myocardial damage further support our hypothesis. Diagnostic and predictive values of these BMPs at the development of post-infarction LVR in vivo should be investigated further.
Keyphrases
- mesenchymal stem cells
- extracellular matrix
- bone regeneration
- acute myocardial infarction
- oxidative stress
- left ventricular
- emergency department
- bone mineral density
- percutaneous coronary intervention
- electronic health record
- high resolution
- big data
- bone marrow
- acute coronary syndrome
- machine learning
- body composition
- postmenopausal women
- artificial intelligence
- soft tissue
- heat stress
- bone loss