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Microfluidic compartmentalization of diffusively coupled oscillators in multisomes induces a novel synchronization scenario.

Marcello A BudroniKristian TorbensenOttorino L PantaniSandra RistoriFederico RossiAli Abou Hassan
Published in: Chemical communications (Cambridge, England) (2020)
Stable cell-like multisomes encapsulating the chemical oscillator Belousov-Zhabotinsky were engineered and organized in a linear network of diffusively-coupled chemical oscillators by using microfluidics. The multi-compartmentalization and the spatial configuration resulted in a new global synchronization scenario. After an initial induction interval, all the oscillators started to pulsate in phase with a halved period with respect to the natural one.
Keyphrases
  • single cell
  • high throughput
  • cell therapy
  • circulating tumor cells
  • stem cells
  • mesenchymal stem cells
  • neural network