Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi.
Ana Carolina Alves de Paula E SilvaCaroline Barcelos Costa-OrlandiFernanda Patrícia GulloFernanda Sangalli-LeiteHaroldo Cesar de OliveiraJulhiany de Fátima da SilvaLiliana ScorzoniNayla de Souza PitanguiSuélen Andrea RossiTatiane BenaducciVanessa Gonçalves WolfLuis Octávio RegasiniMaicon Segalla PetrônioDulce Helena Siqueira SilvaVanderlan S BolzaniAna Marisa Fusco-AlmeidaMaria José Soares Mendes-GianniniPublished in: Evidence-based complementary and alternative medicine : eCAM (2014)
This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.