Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction.

Chen GaoKimberly Howard-QuijanoChristoph RauTatsuo TakamiyaYang SongKalyanam ShivkumarYibin WangAman Mahajan

Published in: PloS one (2017)

Myocardial injury leads to time-dependent global changes in gene expression in the innervating ANS. Induction of inflammatory gene expression and loss of neuron cell viability in SG and DRG are potential novel mechanisms contributing to abnormal ANS function which can promote cardiac arrhythmia and pathological remodeling in myocardium.

Keyphrases

gene expression
dna methylation
left ventricular
oxidative stress
cell death
heart failure
heart rate variability
human health
risk assessment
climate change
atrial fibrillation
catheter ablation