Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer.
Sandra Lucía TenienteAdriana Carolina Flores-GallegosSandra Cecilia Esparza-GonzálezLizeth Guadalupe Campos-MúzquizSendar Daniel Nery-FloresRaul Rodríguez-HerreraPublished in: Antioxidants (Basel, Switzerland) (2023)
Polyphenols are a broad group of bioactive phytochemicals with powerful antioxidant, anti-inflammatory, immunomodulatory, and antiviral activities. Numerous studies have demonstrated that polyphenol extracts obtained from natural sources can be used for the prevention and treatment of cancer. Pomegranate peel extract is an excellent source of polyphenols, such as punicalagin, punicalin, ellagic acid, and caffeic acid, among others. These phenolic compounds have antineoplastic activity in in vitro models of cervical cancer through the regulation of cellular redox balance, induction of apoptosis, cell cycle arrest, and modulation of different signaling pathways. The current review summarizes recent data from scientific reports that address the anticancer activity of the predominant polyphenol compounds present in PPE and their different mechanisms of action in cervical cancer models.
Keyphrases
- cell cycle arrest
- anti inflammatory
- pi k akt
- cell death
- oxidative stress
- signaling pathway
- papillary thyroid
- cell proliferation
- electronic health record
- drinking water
- endoplasmic reticulum stress
- big data
- machine learning
- emergency department
- squamous cell carcinoma
- squamous cell
- combination therapy
- data analysis
- artificial intelligence
- case control
- deep learning
- childhood cancer