Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation.

Mo-Fan Huang Rachel Shoemaker Dung-Fang Lee

Published in: Cellular reprogramming (2022)

By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.

Keyphrases

single cell
transcription factor
rna seq
induced apoptosis
cell cycle arrest
high throughput
gene expression
cell therapy
genome wide
stem cells
dna binding
single molecule
oxidative stress
cell death
signaling pathway
mesenchymal stem cells
heat shock protein
pi k akt