Presence of HIV-1 G-to-A mutations linked to APOBEC editing is more prevalent in non-B HIV-1 subtypes and is associated with lower HIV-1 reservoir.
Basma AbdiSidonie Lambert-NiclotMarc WirdenAude JaryElisa TeyssouSophie SayonRomain PalichRoland TubianaAnne SimonMarc-Antoine ValantinChristine KatlamaLaurence Morand-JoubertVincent CalvezAnne-Geneviève MarcelinCathia SouliePublished in: The Journal of antimicrobial chemotherapy (2021)
These results show an independent association between the presence of G-to-A mutations and stop codons with HIV-1 subtype non-B and low proviral DNA that could be explained by the APOBEC3 footprints and restriction of DNA synthesis and integration. However, further investigations are needed to study the contribution of Vif amino acid variability among HIV-1 subtypes.