Maternal Obesity Modulates Cord Blood Concentrations of Proprotein Convertase Subtilisin/Kexin-type 9 Levels.
Dimitrios RallisAimilia Eirini PapathanasiouHelen ChristouPublished in: Journal of the Endocrine Society (2024)
Neonates born to mothers with overweight/obesity have higher cord blood PCSK9 concentrations compared with the nonoverweight/nonobese group, and higher cord blood PCSK9 concentrations were significantly associated with maternal overweight/obesity status, after adjusting for perinatal factors. Larger longitudinal studies are needed to examine the role of PCSK9 in the development of metabolic syndrome in high-risk neonates born to overweight, obese, or diabetic mothers.
Keyphrases
- cord blood
- weight loss
- metabolic syndrome
- weight gain
- birth weight
- bariatric surgery
- insulin resistance
- low birth weight
- low density lipoprotein
- type diabetes
- gestational age
- physical activity
- high fat diet induced
- preterm infants
- uric acid
- adipose tissue
- pregnant women
- pregnancy outcomes
- cardiovascular risk factors
- skeletal muscle
- cardiovascular disease
- wound healing
- case control