Biglycan promotes hepatic fibrosis through activating heat shock protein 47.
Mengli YuXin-Jue HeXin SongJianguo GaoJiaqi PanTianyu ZhouQinqiu WangWei ZhuHuijian MaHang ZengCheng-Fu XuChaohui YuPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Our data indicate that BGN promotes hepatic fibrosis by regulating ECM deposition and HSC activation through an HSP47-dependent mechanism. BGN may be a new biomarker of hepatic fibrosis and a novel target for disease prevention and treatment.