NMDA receptor binding in focal epilepsies.

Colm J McGinnityM J KoeppA HammersD A Riaño BarrosR M PresslerS LuthraP A JonesW TriggC MicallefM R SymmsD J BrooksJ S Duncan

Published in: Journal of neurology, neurosurgery, and psychiatry (2015)

In patients with focal epilepsies, we detected primarily global increases of [(18)F]GE-179 VT consistent with increased NMDA channel activation, but reduced availability in those taking antidepressant drugs, consistent with a possible mode of action of this class of drugs. [(18)F]GE-179 PET showed focal accentuations of NMDA binding in 4 out of 11 patients, with difficult to localise and treat focal epilepsy.

Keyphrases

dna binding
binding protein
drug induced