Should we depend on reference intervals from manufacturer package inserts? Comparing TSH and FT4 reference intervals from four manufacturers with results from modern indirect methods and the direct method.
Niek F DirksWendy P J den ElzenJacquelien J HillebrandHeleen I JansenEdwin Ten BoekelJacoline BrinkmanMadelon M BuijsAyse Y DemirIneke M DijkstraSilvia C EndenburgPaula EngbersJeannette GootjesMarcel J W JanssenWilhelmina H A Kniest-de JongMaarten B KokStephan KamphuisAdrian KruitEtienne MichielsenAlbert WolthuisAnita BoelenAnnemieke C HeijboerPublished in: Clinical chemistry and laboratory medicine (2024)
These results underscore the importance of RI verification as manufacturer-provided RIs are often incorrect and RIs may not be robust. Indirect methods offer cost-effective alternatives for laboratory-specific or platform-specific verification of RIs.
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