Epac activation induces an extracellular Ca2+ -independent Ca2+ wave that triggers acrosome reaction in human spermatozoa.
Esperanza Mata MartínezAna Alicia Sánchez-TusieAlberto DarszonLuis S MayorgaClaudia L TreviñoGerardo A De BlasPublished in: Andrology (2021)
The Ca2+ wave triggered by Epac activation is necessary to induce the AR and to enhance the flagellar beat.