Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data.
Ning XuYu-Peng WuZhi-Bin KeYing-Chun LiangHai CaiWen-Ting SuXuan TaoShao-Hao ChenQing-Shui ZhengYong WeiXue-Yi XuePublished in: Journal of translational medicine (2019)
Methylated hub genes, including MAOB and RTP4, can be regarded as novel biomarkers for accurate PCa diagnosis and treatment. Further studies are needed to draw more attention to the roles of these hub genes in the occurrence and development of PCa.
Keyphrases
- bioinformatics analysis
- genome wide
- dna methylation
- prostate cancer
- network analysis
- genome wide identification
- risk assessment
- squamous cell carcinoma
- working memory
- gene expression
- high resolution
- electronic health record
- big data
- machine learning
- copy number
- transcription factor
- artificial intelligence
- benign prostatic hyperplasia
- rectal cancer
- mass spectrometry