Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand.
Wen-Qiang HeStephan KarlMichael T WhiteWang NguitragoolWuelton MonteiroAndrea KuehnJakub GruszczykCamila T FrançaJetsumon SattabongkotMarcus V G LacerdaWai-Hong ThamIvo MuellerPublished in: PLoS neglected tropical diseases (2019)
Our results indicate that PvRBP2b warrants further preclinical development as a blood-stage vaccine candidate against P. vivax. Total IgG responses to PvRBPs were also shown to be promising immunological markers of exposure to P. vivax infection.